Project Background

TECNO_EN-P project intends to make available an innovative enabling technology for production chain (TECNO_EN-P) to support the new technology development able to ameliorate the current filtering systems. These findings will permits to development a range of new DMs acting to improve the current therapies as well as an increase of therapeutical applications.


The project aims to develop new medical devices constituted by smart materials, acting to optimize filtration systems and make them more performing in 'insulation / depletion of the target elements. We could achieve the purpose thanks to the innovative TECNO_EN P-enabling system with their controlled and modulated specificity, and greater selectivity and yield compared to current solutions.


TECNO_EN_P aims to develop new technologies to improve existing filtration systems. The materials obtained in the project will allow to: 1) combine filtration and selective removal in a single DM, reducing costs and disposal; 2) have appropriate speed flows and not change electromedical therapies; 3) industrialize the production process and provide for new therapeutic applications of DM.

Action plan

The project provides to develop applied research activities aimed to obtaining new generation of smart materials. Several small-scale samples will be produced for each target of cell or metabolites to deplete and after proper efficacy test, the best performing sample will be selected and then use for large-scale production. A major part of the project will reserved to evaluation of the safety, biocompatibility and efficacy of smart material , allowing to the final step of prototype manufacturing and material validation. Parallel, the project provides a better dissemination and improvement on the reference supply chain, thanks to creation of a demonstration laboratory.


TPM – Tecnopolo Mirandola (MAB)

Microscopy Applied to Biology (MAB) is involved in new assays of biocompatibility and toxicity using stem cell un/differentiate versus a specific tissue. Techniques of advanced microscopy are applied to detect any kind of biological specimen adhered on a materials. Biocompatibility studies can be performed in an mouse model using in vivo imaging techniques.
Reference person: Massimo Dominici; Elena Veronesi


CIRI SdV – Centro Interdipartimentale di Ricerca Industriale Scienze della Vita e Tecnologie per la Salute

The CIRI-SDV laboratory has expertise in the design, fabrication and characterization of innovative polymeric materials for biomedical applications. In the laboratory there are skills of nanotechnology such as electrospinning technology and surface modification and functionalization of materials and polymeric biomaterials.
Reference person: Prof.ssa Maria Letizia Focarete (responsabile scientifico)



CIRI-MAM operates in the fields of Advanced Mechanics and Materials. In the project TECNO-EN-P is involved the group for Industrial Applications of Plasmas, which has consolidated experience in the production, scale-up and miniaturization of equilibrium and non-equilibrium plasma systems at atmospheric pressure, in their characterization and application in many industrial processes.
Reference person: Vittorio colombo



Democenter-Sipe Foundation is an innovation center of the High Technology Network of Emilia-Romagna Region. Democenter-Sipe supports innovation acting as a facilitator and interface between research centers, public bodies and companies, dealing with the dissemination and transfer of the research activities and results.
Reference person: Laura Aldrovandi


Fresenius HemoCare Italia S.r.l.

Fresenius Kabi is an international health care company specializing in life-saving drugs and technologies for infusion, transfusion and clinical nutrition. The products and the company's services are used in the treatment of critical and chronic patients . In the Plant located in Mirandola (Fresenius Hemocare Italia) resides a center of excellence for the design and production of biomaterials and filtering systems for blood treatment.
Reference person: Serena Borghi


B. Braun Avitum Italy S.p.A.

BBraun is one of the world's leading providers & manufacturers of healthcare solutions. BBraun is a family company that was founded in 1839 by J.Wilhelm Braun at Melsungen (Germany). With its constantly growing portfolio of medical care solutions, BBraun makes a contribution to protecting & improving people's health. The company’s operations are organized into four divisions (Hospital Care, Aesculap, Out Patient Market, BBraun Avitum), and it is led by a eight member Management Board.
Reference person: Giuliana Gavioli


Eurosets S.r.l.

Eurosets S.r.l. borned in Medolla (MO) in 1991 and in 1998 became part of Villa Maria Group Care & Research. Actually it is recognized as a leading manufacturing company for Autotransfusion, Cardiac Surgery and Orthopedic devices. Thanks to the technological continuous innovation and to the 129 persons employed, Eurosets achieved 13% as CAGR in the last few years with almost 75% of sales abroad. Eurosets S.r.l. owns more than 20 patents of which 6 deposited in the last 2 years. Innovation and Technology for a Better Patient Outcomes is the daily mission that drives the company.
Reference person: Dott. Antonio Petralia (Vicepresident, Technical Scientific Director, Clinical Manager)


Project POR FESR 2014-2020, AXIS 1 Research and Innovation. 1.2.2 Action